It is important to note that the dog product should only be used on dogs while the cat product should only be used on cats. Not for human use. Observations at the application sites included damp, stiff or greasy hair, the appearance of a white deposit on the hair, and mild erythema, which resolved without treatment within 2 to 48 hours. b Although there is no specific antagonist for avermectin toxicity, even severely affected dogs have completely recovered from avermectin toxicity with intensive veterinary supportive care. To report suspected adverse events and/or obtain a copy of the SDS or for technical assistance, call Bayer Animal Heath at 1-800-422-9874. Adverse reactions in dogs treated with Advantage Multi for Dogs included hematochezia, diarrhea, vomiting, lethargy, inappetence, and pyoderma. One tube of appropriate size should normally be applied topically every 30 days. Advantage Multi is protected by one or more of the following U.S. patents: 6,232,328, and 6,001,858. Efficacy of topically administered fluralaner or imidacloprid/moxidectin on dogs with generalised demodicosis Monthly imidacloprid application of 7.5 to 10 mg/kg will rapidly kill existing and reinfesting flea infestations on dogs and break the flea life cycle by killing adult fleas before egg production begins. Using the correct dosage about 15 CC's will work... like i said above , it didn't work very well for me on ticks, but it will kill fleas. The safety of Advantage Multi for Dogs has not been established in breeding, pregnant, or lactating dogs. Exposure to the product has been reported to cause headache; dizziness; and redness, burning, tingling, or numbness of the skin. Advantage Multi for Dogs has not been evaluated in heartworm-positive dogs with class 4 heartworm disease. At 40% of the minimum recommended topical dose, 4 of the dogs experienced neurological signs indicative of avermectin toxicity including depression, ataxia, mydriasis, salivation, muscle fasciculation, and coma, and were euthanized. Imidacloprid and moxidectin is not recommended for use in kittens less than 9 weeks of age or less than 2 pounds. Vomiting was seen in one puppy from the 1X treatment group (day 57), in two puppies from the 3X treatment group (days 1 and 79), and in one puppy from the 5X treatment group (day 1). (redirects here from imidacloprid) Learn about Advantage for dogs, dosage information, side effects, safety information and uses of this substance can be found here. (See Contraindications, Warnings, Human Warnings, and Adverse Reactions, for more information.). Imidacloprid and moxidectin should not be used in animals with known hypersensitivity or allergy to the drug. Dogs over 88 pounds should be treated with the appropriate combination of tubes. Effectiveness against circulating D. immitis microfilariae was > 90% at five of six sites; however, one site had an effectiveness of 73.3%. Advantage Multi™ is a combination of two drugs, imidacloprid and moxidectin, that act to treat or prevent a variety of parasites. 7.5 mg Advantus Soft Chews contain 7.5 mg imidacloprid per chew for dogs 4 - 22 lbs. Federal (U.S.A.) Law restricts this drug to use by or on the order of a licensed veterinarian. Spotted areas may appear wet or oily for up to 24 hours. Use with caution in sick, debilitated, or underweight animals. Imidacloprid and moxidectin may interact with other medications. Dogs treated with imidacloprid, including those with pre-existing flea allergy dermatitis have shown clinical improvement as a direct result of elimination of fleas from the dog. For dogs, the recommended minimum dose is 4.5 mg/lb. Advantus (imidacloprid) Oral Dog Flea Treatment, Soft Flea Chews for Dogs 23-110 lbs, 30 doses 4.3 out of 5 stars1,395 K9 advantix II Flea and Tick Prevention for Medium Dogs, 11-20 … Before using or dispensing any product, read and carefully observe the label directions. If eye irritation develops or persists, contact a physician. In households with multiple pets, keep each treated dog separated from other treated dogs and other pets for 30 minutes after application to prevent licking the application sites. Treatment and Control of Intestinal Nematode Infections: For the treatment and control of intestinal hookworm infections caused by Ancylostoma caninum and Uncinaria stenocephala (adults, immature adults and fourth stage larvae) and roundworm infections caused by Toxocara canis (adults and fourth stage larvae), and Toxascaris leonina (adults), and whipworm infections caused by Trichuris vulpis (adults), Advantage Multi for Dogs should be administered once as a single topical dose. Field Study: In a controlled, double-masked, field safety study, Advantage Multi for Dogs was administered to 128 dogs of various breeds, 3 months to 15 years of age, weighing 4 to 157 pounds. In case of allergic reaction, contact a physician. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Puppies 2 to 8 weeks old treated once at up to 20x the therapeutic dose (200 mg/kg) showed no adverse effects. In a field safety and effectiveness study, Advantage Multi for Dogs was administered to 92 client-owned dogs with sarcoptic mange. The treatment schedule should be based on individual veterinary diagnoses and on the local epidemiological situation. Dog medications dosage requirements are generally calculated by weight and measured in mg of medicine per pound of body weight. Heartgard dosage is a minimum of 6 mcg/kg (2.72 mcg/lb). Medication should never be administered without first consulting your veterinarian. This drug should only be used in dogs after a negative heartworm test. Imidacloprid + moxidectin is available in 4 sizes for dogs and 2 sizes for cats (based upon body weight). (See WARNINGS.). Two puppies each in the 1X, 3X, and 5X groups had decreased appetites within 24 hours post-dosing. Gloves worn to pat the dogs contained an average of 254 ppm of imidacloprid 24 hours following application of the product. Assurity Plus Spot On works rapidly to control fleas, killing over 98% of adult fleas within 12 hours of application. 4. Consult with your veterinarian to determine if other drugs your pet is receiving might interact with imidacloprid and moxidectin. Even the biggest dose, for dogs over 40kg, is less than a teaspoon. Keep out of reach of children. Serious reactions, including neurologic signs and death have been reported when cats have been exposed (orally and topically) to this product. Two dogs vomited, one at 6 hours and one at 6 days post-treatment. Advantage Multi for Dogs may be administered year-round or at a minimum should start one month before the first expected exposure to mosquitoes and should continue at monthly intervals until one month after the last exposure to mosquitoes. Do not apply an amount of solution at any one location that could run off the side of the dog. Description. Tubes/pipettes are available in sizes of 0.4 ml (for dogs 3-9 pounds), 1 ml (for dogs 9.1 – 20 pounds), 2.5 ml (for dogs 20.1 to 55 pounds), and 4 ml (for dogs over 55.1 to 88 pounds). 2. The recommended minimum doses for dogs are 10mg/kg bodyweight imidacloprid and 2.5mg/kg body weight moxidectin, equivalent to 0.1ml/kgbody weight Endectrid for dogs. One puppy in the 1X treatment group had pruritus for one hour following the fifth treatment. For dogs weighing more than 20 lbs., place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at 3 or 4 spots on the top of the backline from the base of the neck to the upper back in an area inaccessible to licking. Advantage Multi for Dogs kills adult fleas and is indicated for the treatment of flea infestations (Ctenocephalides felis). Updated: 2020-12-31. Imidacloprid is a chloronicotinyl nitroguanidine insecticide. No clinical abnormalities were observed. ©Copyright 1999 - 2021. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. The dogs ranged in age from 2 months to 12.5 years and ranged in weight from 3 to 231.5 pounds. Residues from the fur declined to an average of 4.96 ppm by the end of the first week. No fleas and no problems. Dogs treated topically every week at 5x the therapeutix dose during 8 weeks showed no adverse effects. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. Side effects are uncommon but may include irritation at the application site, or, if the medication is accidentally ingested, drooling, shaking, vomiting, and decreased appetite. Microfilariae counts decreased with treatment. , Advantage Multi ® for dogs is not recommended for use in kittens less than a teaspoon skin is.. Drug experience reporting for Animal drugs, imidacloprid or moxidectin should administer the against! Warnings, and 5X groups had decreased appetites within 24 hours following application of the tube protected one. 50 of technical imidacloprid for a minimum of 12 hours following each treatment of. 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